All tissues release extracellular vesicles (EVs) that may modulate the environment and mediate intercellular communication. EVs carry e.g. bioactive enzymes, RNAs and lipids and have recently been recognised as promising therapeutic agents and biomarkers. We believe in communication, when it comes to cells. They need to talk to each other and we believe this is in large part mediated by extracellular vesicles (EVs).

In B cells, EV release may mediate antigen extraction at immune synapses or shield cancer cells from antibody treatment. However, basic information on the functions and characteristics of B cell EVs is scarce, and nothing is known about the EV-based communication between B cells, which is relevant for lymphoid environments consisting mainly of B and T lymphocytes. In our research, we will critically address the biology behind B cell EV-mediated communication and their impact on activating other B and T cells.